Cold Agglutinin Syndrome
نویسندگان
چکیده
منابع مشابه
Cold agglutinin disease.
Cold agglutinin disease is a rare and poorly understood disorder affecting 15% of patients with autoimmune hemolytic anemia. We reviewed the clinical and pathologic features, prognosis, and management in the literature and describe our institutional experience to improve strategies for accurate diagnosis and treatment. Retrospective analysis identified 89 patients from our institution with cold...
متن کاملChlorambucil treatment of patients with cold agglutinin syndrome.
T HE COLD AGGLUTININ SYNDROME (C.A.S.) is characterized by high-titre cold agglutinins, a hemolytic anemia, Raynaud phenomena in the cold, various degrees of hemoglobinuria, and sometimes gangrene. Because of the hemolysis, the syndrome is most often classified as an autoimmune hemolytic anemia. However, treatment with ACTH, corticosteroids or splenectomy, most often used in this condition, has...
متن کاملThe variability of hemolysis in the cold agglutinin syndrome.
The amount of lysis effected by cold agglutinins is directly related to the ability of the antibody to initiate complement activation. This ability is modified by the concentration of antibody, its thermal amplitude (the highest temperature at which the antibody will react with the cell), the degree to which antibody fixation is modified by the presence of complement components (particularly C3...
متن کاملCold Agglutinin Disease; A Laboratory Challenge
INTRODUCTION Autoimmune haemolytic anemia (AIHA) is a complex process characterized by an immune reaction against red blood cell self-antigens. The analysis of specimens, drawn from patients with cold auto-immune hemolytic anemia is a difficult problem for automated hematology analyzer. This paper was written to alert technologists and pathologists to the presence of cold agglutinins and its ef...
متن کاملHow I manage cold agglutinin disease.
Primary chronic cold agglutinin disease (CAD) is a clonal lymphoproliferative disorder accounting for 13-15% of autoimmune haemolytic anaemias. Significant advances have been made in treatment, which was largely unsuccessful until recently. The essential clinical, immunological and pathological features are reviewed, focusing on their relevance for therapy. Non-pharmacological management still ...
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ژورنال
عنوان ژورنال: Laboratory Medicine
سال: 2002
ISSN: 1943-7730,0007-5027
DOI: 10.1309/bpg6-axbv-mj4t-g7cc